17P (Hydroxyprogesterone):

Progesterone Used For Prevention of Preterm Labor

The 17P (Hydroxyprogesterone) or 17-alpha hydroxyprogesterone caproate medication is sometimes given to pregnant women that have experienced preterm labor. There has been some research that seems to show that the results are promising in prevention of preterm birth in high risk pregnancies. This medication is only accessible through prescription from specialty pharmacies that compound sterile products.

17P shots are usually started between weeks 16 and 20 in pregnancy, and are stopped at or around week 36 of pregnancy. They typically are administered weekly by a doctor or home health aide.

What is 17-alpha Hydroxyprogesterone Caproate?
(also 17-AHPC)

Hydroxyprogesterone caproate is a progestogen that is related structurally to progesterone that is commonly used for recurrent miscarriage and other menstrual disorders. Suggested doses have been 250 to 500 mg weekly by intramuscular injection during the first half of pregnancy.

Is it safe for fetus?
According to OB Gyn studies, treatment of high risk pregnant women with a progesterone hormone during the 2nd and 3rd trimester is said to be safe for the fetus. To maintain a pregnancy, high levels of progesterone are produced by the placenta. If there is a drop in the levels, it is thought to be a stimulate of the onset of labor. It is repeated that 17 alpha-hydroxyprogesterone caproate has shown to reduce repeat preterm births, but it still remains unclear whether the treatment is absolutely safe for the fetus.

Recent studies from Obsterics and Gynecology, October 2007, show that there is no evidence that the hormone impaired development and no link with congenital malformations. The investigators conclude the study provides reassurance that the 17 alpha-hydroxyprogesterone caproate is safe for the fetus when administered in the 2nd and 3rd trimesters.

Are there any side effects for mom?
Common responses that I personally have heard from patients that use this treatment is temporary swelling around the injection site. It lessens toward the end of the week. Other women have said that there can be itching around the injection site. The shots may sting initially for a few seconds as the medication starts to flow, but all in all, they believe the treatment is totally worth it!

Be sure to check with your physician to see if 17P shots are right for you. He should be able to advise you of when the shots are to be started during your pregnancy. It is also important to check with your insurance company to be sure that you are covered for this treatment.

Progesterone is also given for treatment for infertility as well.

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